Akura™ plates

Unique Akura™ PLUS Hanging Drop System in a 96-well format with automation-compatible top-loading.

The world-famous and unique Akura™ PLUS Hanging Drop System in a 96-well format with automation-compatible top-loading.
• Loading of cell suspension from the top through unique SureDrop™ inlet engineered for highly uniform and stable hanging drops
• Gravity-assisted formation of uniform spheroid/organoid morphology and functionality in long-term cell culture results in one spheroid per well
• Suitable for many cell types, including cells that don't normally form spheroids or organoids on ultra-low attachment surfaces

The Akura™ 96 Spheroid Microplate is designed for lossless spheroid/organoid formation and handling as well as reliable cell culturing and analysis.
• All-in-one plate allowing spheroid formation, long-term culturing and analysis in one single plate
• Unique SureXchange™ ledge engineered to prevent unintended spheroid aspiration and to retain consistent minimal residual volume (5 -7 µl) during medium exchange
• Spheroid morphology and functionality are preserved in long-term cell culture by unique ULA coating
• Enhanced imaging speed and resolution through flat bottom well

Cat no. 418903
• The Akura™ ImagePro is a high-end solution plate that unifies robust liquid and spheroid handling with automated high-resolution imaging
• The flat bottom and black walls of the 384 well plate facilitate high-resolution, high-content imaging, while the special well design allows medium exchange, dosing, and endpoint determination in the same plate saving time and resources
• Unique SureXchange™ ledge engineered to prevent unintended spheroid/organoid aspiration and to retain consistent minimal remnant media volumes (< 2-3 µl) during medium exchange
• Superior high-content imaging quality with a continuous, flat-bottom, 25 µm gas-permeable membrane, and a black-walled body

Cat no. 418904
• The Akura™ 384 Spheroid Microplate is a ultimate spheroid screening plate unifying robust liquid and spheroid handling with automated high-throughput screening applications
• The flat bottom and black walls of the InSphero 384-well plate facilitate fluorescent imaging, while the special well design allows medium exchange, dosing, and endpoint determination in the same plate saving time and resources
• Unique SureXchange™ ledge engineered to prevent unintended spheroid/organoid aspiration and to retain consistent minimal residual volume (2-3 µl) during medium exchange
• Fluorescent imaging quality with a continuous, flat-bottom, 125 µm Polystyrene membrane, and a black-walled body

Cat no. 418905
Incubox™protects your microplates from evaporation effects.
The InSphero Incubox™ is a specially engineered container that creates a high-humidity microclimate inside conventional cell culture incubators and protects your sensitive plates from large humidity drops and fluctuations (the major cause for evaporation effects).
• Maintain a stable medium volume and accurate compound concentration due to minimal evaporation over time
• Reduce well-to-well variation by minimizing evaporation-induced reagent gradients across the plate
• Use all wells of your plate by eliminating edge effects in your culture plate
• Save on plasticware by using up to 38% more wells of your plate

Cat no. 418906
Stable tilting of Akura™ Microplate for improved spheroid uniformity.
The Akura™ Tilting Stand is a convenient multi-purpose tool for different handling steps with the Akura™ Plate family.
• Keeps plates at an angle of 30 degrees during cell aggregation improving spheroid/organoid uniformity
• Improved spheroid uniformity through tilting of Akura™ 96/384 Spheroid Plates and directing cells to the edge of the well for efficient aggregation
• Safe stacking of up to 4 plates for parallel spheroid/organoid formation
• Incubator safe and reusable through simple cleaning and sterilization

Part no. 418907
All-in-One Solution for DILI Compound Testing with Primary 3D Hepatocyte Spheroids.
The Akura™ 3D SureKit provides a validated all-in-one solution to generate and culture organotypic 3D spheroids from primary human hepatocytes.
The 3D SureKit contains frozen primary human hepatocytes and specialized media to aggregate the cells and culture the formed spheroids. 3D optimized Akura™ 96 Plates are included to allow for reliable aggregation and loss-free media exchanges. Reference characterization data and dose-response curves for model DILI compounds are provided as benchmark data for your in-house experiments.
• Hepatocyte lot tested for 3D spheroids formation
• Akura™ 96 Spheroid Microplates, which guarantee homogenous aggregation of cells and minimal tissue loss during media exchanges
• InSphero proprietary aggregation and culture media, which are essential for generating and maintaining spheroids
• Access to QC data and protocols